Models for correlating the composition of the gut microbiota (GM) with inflammatory disease parameters in animal models’

Project responsibles:

Axel Kornerup Hansen, Professor (grant holder), Department of Veterinary Disease Biology (IVS).

Dennis Sandris Nielsen (main supervisor), Associate professor, Department of Food Science/Food Microbiology (IFV).
Lukasz Krych, PhD student, Department of Veterinary Disease Biology (IVS).
 

Involved people and partners:

Finn Kvist Vogensen, Associate professor, Department of Veterinary Disease Biology (IVS).

Frans van der Berg, Associate professor, Department of Food Science/ Quality and Technology (IFV).

Novo Nordisk A/S
LeoPharma A/S

 

Project description

There is growing evidence showing a link between gut microbiota (GM) diverse composition and stimulation of the immune system, as well as subsequent development of many autoimmune and inflammatory diseases in humans such as type 1 diabetes, atherosclerosis (ATS), rheumatic arthritis (RA) and colitis (COL). Disturbances in energy harvesting from diet and/or improper energy storage in hosts due to GM composition imbalances, leads to obesity and all kind of so-called obesity-related disorders such as type 2 diabetes or hypertension. All these disorders have a very similar etiology and course in animal models such as mice, and thus could be use for elucidation how the gut microbiota influence human health and disease.

The aim of the present project is to develop models for correlating the composition of the gut microbiota with inflammatory disease parameters using animal models. The project will be carried out in collaboration between Department of Food Science and Department of Veterinary Disease Biology.